Symbol
Name
ID

Pparg
peroxisome proliferator activated receptor gamma
MGI:97747

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Thrombocytopenia	Splenomegaly	Hepatosplenomegaly
Disease(s) Associated with PPARG	Thrombocytopenia	Splenomegaly	Hepatosplenomegaly
familial partial lipodystrophy type 3
pancreatic cancer
pre-eclampsia

Mouse Phenotypes

hematopoietic system phenotype

abnormal osteoclast differentiation

increased B cell proliferation

impaired macrophage phagocytosis

enlarged spleen

abnormal T-helper 17 cell differentiation

extramedullary hematopoiesis

abnormal bone marrow cell morphology/development

decreased bone marrow cell number

abnormal hematocrit

decreased hematocrit

decreased osteoclast cell number

abnormal osteoclast morphology

abnormal peritoneal macrophage morphology

abnormal spleen morphology

abnormal splenocyte morphology

increased splenocyte number

abnormal B cell physiology

increased IgG level

increased IgM level

abnormal macrophage physiology

abnormal macrophage activation involved in immune response

leukostasis

Availability

Mouse Genotype

Pparg^tm1Tka/Pparg⁺

Pparg^tm1.1Gonz/Pparg^tm1.1Gonz
Tg(Mx1-cre)1Cgn/? (conditional)

Pparg^tm1.1Gonz/Pparg^tm1.1Gonz
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Pparg^tm1.1Gonz/Pparg^tm1.1Gonz
Tg(Aqp2-cre)1Dek/0 (conditional)

Pparg^tm2Rev/Pparg^tm2Rev
Tg(Tek-cre)1Ywa/? (conditional)

Pparg^tm2Rev/Pparg^tm2Rev
Tg(Cd4-cre)1Cwi/? (conditional)

Pparg^tm2Rev/Pparg^tm2Rev
Tg(Tek-cre)12Flv/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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